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Pioglitazone is a antidiabetic drug, which undergoes hepatic degradation and have poor bioavailability (40%). For overcoming this problem Fast dissolving film of Pioglitazone Hydrochloride is formulated by employing Solvent casting technique with suitable film forming agent; HPMC and Sodium Starch glycolate in a different proportion. The prepared film avoids extensive first pass metabolism and improvement in dissolution efficacy, disintegration time which results in improvement in bioavailability. The advantage of this formulation is such that in case of shoot of blood glucose level in patient can take the drug without the usage of water. Therefore the main objective of the present work is to develop Fast dissolving films for Pioglitazone Hydrochloride to improve bioavailability, disintegration time, dissolution efficacy and patient compliance.

KEYWORDS: Solvent Casting Technique, Film forming agent, Sodium Starch Glycolate, Betacyclodextrine