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Background: Chronic lead poisoning (plumbism) remains a significant global public health concern, particularly in populations exposed to industrial, occupational, and environmental lead sources. Conventional chelation therapy, while effective in reducing blood lead levels, is associated with adverse effects and incomplete reversal of neurological and systemic sequelae. Homoeopathic medicine, particularly Zincum Metallicum and related remedies including Plumbum Metallicum, Natrum Sulphuricum, and Causticum, offers an integrative therapeutic lens for managing chronic lead toxicity by addressing the totality of symptoms.

Objective: To critically review and compile available evidence — classical, clinical, and experimental — on the utility of Zincum Metallicum and other homoeopathic remedies in the management of chronic lead poisoning.

Methods: A comprehensive literature review was conducted across PubMed, Google Scholar, Cochrane Library, AYUSH Research Portal, and classical homoeopathic repertories and materia medica texts. Search terms included 'homoeopathy lead poisoning', 'Zincum Metallicum toxicology', 'Plumbum Metallicum chronic poisoning', and related terms. Primary homoeopathic materia medica sources (Clarke, Kent, Boericke, Allen) were analysed for lead-symptom cross-references.

Results: Zincum Metallicum addresses a characteristic cluster of neurological suppression, motor weakness, restlessness, and cognitive decline that mirrors the neuropathological profile of chronic lead exposure. Plumbum Metallicum directly prepared from lead exhibits homeopathic symptom similarity with plumbism. Supporting remedies including Natrum Sulphuricum, Causticum, and Belladonna address overlapping organ-specific manifestations.

Conclusion: Homoeopathic remedies, particularly Zincum Metallicum and Plumbum Metallicum, demonstrate significant symptom-totality overlap with the clinical picture of chronic lead poisoning. Controlled clinical trials are warranted to validate these classical clinical observations.

Keywords: Zincum Metallicum; chronic lead poisoning; plumbism; Plumbum Metallicum; homoeopathic materia medica; integrative toxicology; heavy metal toxicity