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The universal role of plants in disease treatment is well established through their use in herbal medicine. Understanding medicinal plants requires knowledge from multiple disciplines, including botany, horticulture, chemistry, pharmacology, genetics, enzymology, and quality control. Despite significant advances in medicine, many plant species with potential therapeutic value remain unexplored, and continuous research is being conducted to identify their pharmacological applications.

This review focuses on the bone regenerative potential of Amorphophallus paeoniifolius, commonly known as Elephant Foot Yam, Suran, Kanda, or Jimikand. Periodontitis is a chronic inflammatory disease of the oral cavity that causes progressive destruction of periodontal tissues, including the periodontal ligament and alveolar bone, ultimately leading to tooth loss. Regenerative therapies such as guided tissue regeneration (GTR), bone grafting, and biomaterial-based approaches are commonly used to restore damaged tissues and promote new bone formation.

Bone regeneration is a complex biological process involving osteoblasts, osteoclasts, extracellular matrix formation, and growth factors that coordinate tissue repair. Recent interest in plant-based therapeutics has encouraged the investigation of natural agents capable of supporting bone healing by reducing inflammation, controlling oxidative stress, and stimulating osteoblastic activity.

Among these natural agents, Amorphophallus paeoniifolius has attracted attention because of its antioxidant-rich composition and possible bioactive compounds that may aid cellular repair and bone regeneration. Preliminary findings suggest its potential supportive role in periodontal therapy; however, further in vitro, in vivo, and clinical studies are necessary to confirm its efficacy, safety, and exact mechanism of action in periodontal bone regeneration.

Key word: Dioscorea yams, Amorphophallus Paeoniifolius, Periodontitis, Bone regeneration, Jimikand, Suran, Guided tissue regeneration.