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Infertility means a man or woman is not being able to reproduce after one year of unprotected intercourse. Approximately 10 to 15% of partners are affected by infertility. In entire cases of infertility, man is directly responsible in about 30-40%, the female in 40-50% and both are responsible in 10% cases. The study was designed to find out the relation between infertility and modern life-style. In results - psychological Stress, smoking, coffee, alcohol, Pesticides, plastic items, Medicines like – Spironolactone, Nitrofurantoin, etc. Perfluorooctanoic acid in coated non-stick vessels, nonylphenol in detergent etc are found as major risk factor for infertility. In inference, the crucial role that lifestyle factors play in the development of infertility has generated a considerable amount of interest. Lifestyle factors are the modifiable habits and ways of westernise life that can greatly influence overall health and well-being, including fertility. The present literature review includes several lifestyle factors and places infertility in context for the both males and females; it aims to find the roles that lifestyle factors have major role in determining reproductive status. Other factors such as testicular heat stress, intense cycling training, lack of sleep and exposure to electromagnetic radiation from mobile phone use are briefly discussed.