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INTRODUCTION: Depression is a chronic, enduring illness that may necessitate lifetime therapy utilising a range of techniques. Premature death is more common in depressed patients as compared to controls. By addressing chemical imbalances of neurotransmitters in the brain. Antidepressants are a class of medications used to treat the signs and symptoms of depressive disorders. The market is flooded with antidepressant medications. Unfortunately, despite the proliferation of new antidepressants that have recently entered clinical use, the effectiveness plateau that the traditional antidepressants displayed has not been reversed. The search for a more effective antidepressant that is also more tolerable, acts quickly, and has fewer side effects.MATERIAL &METHOD: The current research project's objective is to create innovative tricyclic antidepressants as ß-carboline analogues (pyrido(6,5-b) indoles). For this purpose, the chemical study was carried out. The information for the present study was obtained from various internet sources like research articles and paper presentation documents and research book publications. According to the acquired source, the research is based on secondary data gathered from sources. RESULT & DISCUSSION: The current compound was created to have the ß-caroline-like activity of a selective MAO-A inhibitor. Due to its potential to increase brain monoamine levels, it was believed that the developed chemical, 2-substituted 1,3,4-oxadiazino[6,5-b] indole, would have an antidepressant effect. According to the study, the molecule's 8 possible derivatives were all created. By esterifying amino acids with methanol while thionyl chloride was present, amino acid esters, the beginning chemical, were created. Esters were next converted to hydrazides, and sulphuric acid was used to cyclize these hydrazones to produce the desired tricylic product. Accordingly, the physicochemical characterization of the 8 synthesized derivatives was carried out by melting point determination, TLC, IR spectra and HNMR spectra.