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Chikungunya fever (CHIK) is an emerging, mosquito-borne disease caused by an alphavirus, Chikungunya virus(CHIKV) that causes fever and debilitating joint pains in humans. It is vectored primarily by the tropical and sub-tropical mosquito but Aedes aegypti
is also found to be transmitted by Aedes albopictus. Studies shows that musculoskeletal problem remain present for weeks, months and years after onset of chikungunya fever. Rasnapanchaka kwatha mentioned in Bhaisajyaratnavali as a therapeutic formulation to treat Asthi-Majjagata Vata. Rasnapanchaka kwatha was used to as shamana therapy in Post-Chikungunya Chronic Inflammatory Rheumatism. Aims: To carried out stability of coarse powder of Rasnapanchaka kwatha with respect to its microbial profile. Materials and Methods: Sample of Coarse powder of Rasnapanchaka kwatha was prepared and studied to check microbial contamination at regular intervals. Results: Every time sample was subjected to the microbiological study from the date of the preparation to the date of last microbiological study. No any contaminations was found in microbiological study. Discussion: Hence the present Study was carried out to observe the stability study of coarse powder of Rasnapanchaka kwatha with respect to Microbial Contamination of sample prepared and preserved in different climatic and temperature conditions. Thus a baseline Microbial profile was studied at regular interval as consumption of drug for patient’s usage. At the end of study it was found that sample was not showed presence of any Microbes. Conclusion: At the end of study Rasnapanchaka kwatha container has not present of microbes after 15 month of preparation sample, even in different climate and temperature. Hence in present study the stability test of Rasnapanchaka kwatha with respect to microbiological findings was negative at room temperature, warm and cold, dry and humid conditions.

KEY WORDS: Stability, Microbial profile, Chikungunya, Post-Chikungunya Chronic Inflammatory Rheumatism, Rasnapanchaka kwatha, Climate conditions.