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“Baobab” a well-known plant botanically known as Adansonia digitata L. belongs to the family Bombacaceae. It is an incredible deciduous tree known for its therapeutic and ethnomedicinal values. It is native to Africa, also found in India in Uttar Pradesh, Bihar, Bombay, Gujarat, and Madras. The plant is well documented in Ayurvedic Nighantus for its medicinal purpose. The fruit pulp, seeds, leaves, flowers, and bark of the plant are edible and used traditionally as foodstuff and also to treat various ailments such as in digestive disorders, diarrhea, fever, and malaria, etc. Phytochemical investigation revealed the presence of flavonoids, phytosterols, triterpenoids, polyphenols, amino acids, fatty acids, vitamins, and minerals. It has a numerous number of biological activities such as antimicrobial, antiviral, anti-oxidant and anti-inflammatory, etc. This review summarizes the Botanical aspects, Ayurvedic aspects Ethnopharmacology, Phytochemistry and Biological properties of the plant safeguarding it for human health.