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There has always been  an emphasis on acquiring a balanced state of health and prevention from diseases in ancient texts of  Ayurveda .Even though concepts  on immunity in conventional science is highly developed but acquiring the same in terms of physical and mental strength (Dehabala and Manobala ) still needs to be explored adequately. Prognosis of every disease has certain underlying etiology.  Whether age, unwholesome food practices, addictions or invasion of micro organisms, environmental   factors all these can contribute to the  precipitation of diseases . Hence science from ancient Ayurveda   provides  certain therapeutic  management  that can help not only combating disease but simultaneously avoid  its relapse..Rasayan and Vajikaran are such unique divisions amongst all in Ayurveda   that  describes the concept of longevity apart from immunity.This article deals with various aspects of Rasayan along with its necessity in modern era.