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Controlled and sustained drug delivery has become standard in modern drug design. The in situ gel system is one of the best novel drug delivery system. In situ gelling formulations are drug delivery system which exist in a liquid form at room temperature and change into gel state after application to the body. In situ gelling system explain about gels which are defined as intermediate state of matter consist of liquid and solid components. In - situ gels are type of hydrogel, which are in solution form and undergoes gelation under various physiological conditions. The formation of gel depends on temperature, PH changes, viscosity, ion exposure, radiation, enzyme, molecular weight, polymers, UV light. Both natural and synthetic biodegradable    polymers are used for formulation of in situ gels such as Poloxamer, Pectin, HPMC (Hydroxypropyl methyl cellulose), Xyloglucon, Carbopol, Guar gum, Gellan gum, Xanthan gum, Alginic acid. Method includes in In situ gel formulation are solvent evaporation method, phase transition method, eletrospinning process, self emulsifying drug delivery system, iontophoresis process, hydrogels systems process. In situ gel to be used in different drug delivery systems like Oral, Ocular, Nasal, Buccal, Vaginal, Rectal, Dermal, Intravesical. This review mainly focuses on introduction to in situ gel, various applications of  in situ gel, methods for preparation, drug criteria for selection, various polymers used in In situ gel formulation.

KEY WORDS: Polymers, In situ gel, application, gels, controlled and sustained release.