FORMULATION, DEVELOPMENT AND EVALUATION OF OPTHALMIC IN SITU FORMULATION OF NAPROXEN
Ocular drug delivery was considered a challenging approach for many decades, due to the limitation in the bioavailability in addition to the common drawbacks of the conventional eye preparations represented with blurred vision, pre-corneal elimination and high variability. For this reason ion- induced ocular in-situ gel were formulated using gellan gum in three different concentrations (0.1,0.2 and 0.3%) as ion cross-linking polymers in conjugation with HPMC as viscosity enhancer.
The objective of the present study was to develop an ion activated in situ gelling system for Naproxen, so as to increase the precorneal residence time, reduced dosing frequency and improved patient compliance. The formation of gels depends on factors like temperature modulation, pH change, presence of ions from which the drug gets released in a sustained and controlled manner. In situ gel forming solution of Naproxen was developed using Gellan gum as the gelling agent in combination with Hydroxypropyl Methylcellulose (HPMC) which acted as a viscosity-enhancing agent.
The formulation in gel form showed almost complete release of drug over the period 8 of hours.
Keyword: Gellan gum, ophthalmic in situ gelling, sol-gel transition, Naproxen.