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Transdermal patches are inventive drug delivery systems and can be used for executing coherent systemic effect by passing hepatic first pass metabolism and increasing the fraction absorbed. Transdermal patches of Meclozine hydrochloride were developed by the solvent casting evaporation technique using ethyl cellulose: HPMC, Eudragit RSPO, propylene glycol and permeation enhancer using different ratios. The physicochemical parameters such as flexibility, thickness, smoothness, weight variation, moisture content, hardness, folding endurance and tensile strength were estimated for the developed patches. The formulation revealed flexibility, uniform thickness and weight, smoothness, good drug content and little moisture content. The in vitro diffusion studies were carried out using modified Franz diffusion cell using egg membrane as the diffusion membrane and the formulation followed the Korsmeyer-Peppas diffusion mechanism. The formulation containing ethyl cellulose: HPMC as polymers showed faster release rate compared to Eudragit: HPMC. The stability studies indicated that all the patches maintained good physicochemical properties and drug content after storing the patches in discrete storage conditions. Compatibility studies indicated that there was no interaction between the drug and polymers. Hence, the aim of the present study was to prepare the sustained release formulation (Transdermal patches) of the drug using different blend of polymers.