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Nowadays, Alkaline water (pH>7) has gained interest by people for better physiological medium. They drink alkaline water in routine daily schedule. It is found to be safe and most accepted by body. Its safe profile can be explored in the various pharmaceutical, cosmetic and food products. The present study was aimed to explore use of alkaline water in formulation of topical Diclofenac gel comprising Carbopol as main gelling agent. Generally, Carbopol exhibits acceptable consistency in alkaline medium. For the sake of providing alkaline medium, selected chemicals (TEA or NaOH) can be added in Carbopol gel to achieve desired consistency. Trials were taken of for developing Carbopol gel using TEA and alkaline water as basicity provider using diclofenac as a model drug. Diclofenac content in formulations was assessed by UV spectrophotometric method at 276 maximum wavelength. The developed formulations and market product (Vollini® gel) were evaluated for various parameters. The results indicated that alkaline water had proven its equivalency with TEA in performance. Similar kind of drug release pattern was obtained. All three formulations including market          product have shown Higuchi model as best fit model as far as drug release kinetics is concerned. The results of accelerated stability study indicate stable characteristics of developed formulations. So, in a nutshell it can be concluded that alkaline water can be used in place of chemicals to provide basicity (TEA/NaoH). The scope of successful use of alkaline water in similar kind of preparations can be increased.  

 Key words: Alkaline water, Carbopol gel, Diclofenac, Stability study