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The present study was aimed to evaluate the hepatoprotective effect of Jasminum officinale Fruits extract in acute experimental liver injury induced by alcohol in rats. To induce the liver toxicity 24 hour after the last treatment was administered where as for alcohol model alcohol was given for 15 days. Rats were received different treatments such as silymarin (100 mg/kg), low and high doses of Jasminum officinale Fruits extract(100 and 500 mg/kg,) orally. The protective effect of prophylactic treatment was analysed by estimation of serum biomarkers like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and bilirubin (total and direct) and by histopathological observation. The activities of serum biomarkers were significantly decreased in all treated groups compared with toxic control. It was concluded that high and the low dose of Jasminum officinale Fruits extract (JSFE) demonstrated reduced serum biomarkers activity significantly which was supported by histopathological study.