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Background: In today's society, lifestyle has resulted in a plethora of diseases that, while not life-threatening, have a significant impact on everyday life. Neck soreness is one of them continuous working without rest on computers and mobile devices.

Aims and objective: To evaluate and compare the efficacy of Nasya Karma with Mahamasha Taila and Greeva Parisheka with Dashmoola Kwath and combined effect of Greeva Parisheka and Nasya Karma followed by Trayodashanga Guggulu in the management of Manyastambha with special reference to Cervical Spondylosis.

Material and methods: Source of information, Data gathering method, Criteria for inclusion, Criteria for exclusion Criteria for dropping out, drug selection criteria, and so forth. Criteria for diagnosis, Intervention, Research Design Procedure of Panchakarma, Assessment Criteria, Statistical research, Overall evaluation of the entire impact.

Result: The efficacy of Greeva Parishek with Dashmool Kwath in Manyastambha i.e. Group marked improvement in 01 (10%) patient and moderate improvement in 09 (90%) patients. Nasya Karma with Mahamasha Taila showed marked improvement in 05 (50%) patients and moderate improvement in 05 (50%) patients. The combined effect of Greeva Parishek with Dashmool Kwath and Nasya Karma with Mahamasha Taila i.e. Group C provided Marked improvement in 08 (80%) patients and moderate improvement in 02 (20%) patients after completion of treatment. No clinically adverse effect reported during the study.

Conclusion: Slowing deterioration, providing symptomatic relief, preventing future progression, and promoting a sense of well-being were all goals of therapy. Mahamasha Taila Nasya Karma and Greeva Parisheka with Dashmoola Kwath were researched in light of all of these considerations, since it is a very simple approach that is both cost-effective and practical in today's world.

Keywords: cervical spondylosis, Manyastambha, Nasya, Neck pain