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Current study aim is to raise the dissolution rate of a water-soluble drug, Vildagliptin by the solid dispersion technique. Vildagliptin belongs to a class of orally active anti-diabetic drug which inhibits dipeptidyl peptidase-4 (DPP-4) and to raise the emission of insulin in the β-cells, thereby decreasing blood glucose level. Solid dispersion is the system made up of one or more active ingredients which are dispersed in inert carrier in a solid state. SD are classified as follows: first generation as crystalline carriers such as urea, second generation amorphous carriers which are generally polymers and third generation carriers with surface activity properties. Generally it contains surfactant or a mixture of surfactants. They are prepared by the fusion method, solvent method and fusion solvent-method. Eutectic mixtures are also form of solid dispersions which are also prepared by fusion method with the help of specific solvents on the basis of a formulation strategy to improve the physical properties of the active ingredient for the enhanced dissolution rate and solubility.

KEYWORDS – Vildagliptin, Vildagliptin Solid Dispersion, Solid Dispersion Methods