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Depression is a persistent, chronic condition that may require lifelong therapy using a variety of approaches. Multiple lines of evidence point to depression's significant role to medical morbidity. Comparing depressed patients to controls, premature death is more likely in depressed patients. Antidepressants are useful for treating a variety of disorders. Treatment for unipolar major depressive disorders is frequently referred to as antidepressant therapy, which is based on three groups of pharmacological agents: monoamine oxidase inhibitors, monoamine reuptake inhibitors, auto receptor desensitizers, and antagonists. Despite the fact that they cannot treat the condition, they can relieve its symptoms. Therefore, the likelihood of responsiveness to the treatment option, vulnerability to adverse events, and potential advantages and hazards should all be taken into account when selecting ADs. The findings of this review shall help to carefully review the appropriateness of Antidepressants on an individual basis.

KEYWORDS: Depression, Anti- depressants, safety.