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Acne vulgaris, or acne, as it is generally called, is the most common skin disease, affecting nearly 80 percent of persons at some time between the ages of 11 and 30 years.¹ It can persist for years and result in disfigurement and permanent scarring, and it can have serious adverse effects on psychosocial development, resulting in emotional problems, withdrawal from society, and depression.² The pathogenesis of acne is multifactorial, and therapy can now be directed at many of these factors. This review summarizes current concepts of the rational treatment of acne vulgaris.

Objective To review the best evidence available for individualized Ayurvedic treatment of acne.

Study Selection Well-designed randomized controlled trials, meta-analyses, and other systematic reviews are the focus of this article.

Data Synthesis Main outcome measures of 29 randomized double-blind trials that were evaluated included reductions in inflammatory, noninflammatory, and total acne lesion counts.  Glo ON reduce the number of comedones and inflammatory lesions in the range of 40% to 70%. These agents are the mainstay of therapy in patients with comedones only. Other agents, including DermatON, Maha Manjishthadi Kwath &, Dashang lep & Neurova Lep all yield high response rates. Patients with mild to moderate severity inflammatory acne with papules and pustules should be treated with all medicines prescribed above. DermatON are first-line therapy in patients with moderate to severe inflammatory acne while DermatON & GloON is indicated for severe nodular acne, treatment failures, scarring, frequent relapses, or in cases of severe psychological distress. Long-term topical or oral antibiotic therapy should be avoided when feasible to minimize occurrence of bacterial resistance. DermatON is a powerful teratogen mandating strict precautions for use among women of childbearing age.

Conclusions Acne responses to treatment vary considerably. Frequently more than 1 treatment modality is used concomitantly. Best results are seen when treatments are individualized on the basis of clinical presentation.The management of acne vulgaris by non-dermatologists is increasing.1 In this article we attempt to answer the question: what treatments in acne vulgaris have proven efficacy and how are these treatments best administered and individualized to optimize results and minimize complications? We considered the efficacy and safety of topical Dashang lep, Neurova , Tab.DermatON, Tab.GloOn & Mahamanjishthadi Kwatha