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Piper betel leaves were evaluated for its antiasthmatic activity, commonly known as pan. It is having long history to use in India as it has multiple therapeutic activities like antibacterial, lymphangitis, asthma, treating eczema and rheumatism. So selected, the plant P. betel is effective in antiasthmatic activity and antioxidant activity, but antihistaminic activity of P. betel is still not scientifically investigated. In the present study, the pharmacological evaluation of ethanolic extract and essential oil extract of leaves of P. betel has been done for their antiasthmatic and antioxidant activity on goat trachea. Moreover, extracts of P. betel disturbed histamine aerosol induce bronchoconstriction in whole guinea pig, where essential oil was more effective comparatively to ethanolic extract. Thus, from the results obtained in the present investigation, it can be concluded that ethanolic extract and essential oil of P. betel possess antiasthmatic and antioxidant activity.