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Hypertension is a multifactorial clinical condition and therefore can be managed in multiple pathways. Convolvulus pluricaulis (Shankhpushpi), Nordostachys jatamansi (Jatamansi), Terminalia Arjuna (Arjuna), Withania somnifera (Ashwagandha), Boerhavia diffusa (Punarnava) are effectively used to manage hypertension, but each of them has different pharmacological properties and actions mitigating some pathway of hypertension. Therefore a combination of these herbs should fulfill the need of developing a broadspectrum antihypertensive. Each of these herbs is proven to be safe and effective individually. But the safety of the combination (NIA/DG/2015/01) is yet to be established. It is mandatory to do acute toxicity study for new formulations having proven safe ingredients. Therefore a toxicity study was conducted of NIA/DG/2015/01 as per OECD guideline 423. Six albino rats were used for this study in two groups having 3 animals each group, Group1 was given a single oral dose of 2000mg/kg body wt. and Group2 was given 300mg/kg body wt. The animals were observed for OECD prescribes parameters and duration. There was no lethal or toxic effect seen in any of the animals. The present study showed that the test substance NIA/DG/2015/01 does not show any toxicity at 300mg/kg body wt. and 2000mg/kg body wt.