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Background: Marmas being vital points of body should be treated with great precaution and with special attention towards protecting them. De Quervain's disease is a painful inflammation of tendons in the thumb that extend to the wrist (tenosynovitis). Incidence of De Quervain’s disease (tenosynovitis) in young, active population is seen to be more according to National Centre for Biotechnology Information (NCBI-E pub 2008 Dec 10). There were 11,332 cases of De Quervain’s disease (tenosynovitis) in the population at risk of 121, 17, 749 person-year (0.093%). De Quervain’s disease being a disease of Marma Sthana. Same condition is seen in Kurchashir Marma viddha lakshanas. Kurchashir Marma is one of the Rujakar Marma, present in both Urdhva Shakha (upper limb) and both Adho Shakha (lower limb). This study will enlighten the Marma concept behind this disease. Aim: To study Urdhva Shakhagat Kurchashir Marma with special reference to De Quervain’s disease. Materials and methods: All references regarding Kurchashir Marma and De Quervain’s disease were collected from available literatures and reputed websites. Conclusion: The anatomical structures involved in De Quervain’s disease is related to the anatomical structures of the Kurchashir Marma.