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Yukti, a fundamental concept in Ayurveda, plays a pivotal role in achieving the discipline's goals and driving modern research. Like medicinal herbs (Bhesaja), Yukti is versatile, serving as a tool for knowledge acquisition (Pramana), diagnostic evaluation (Pariksha), and therapeutic application (Guna). Charaka, a renowned Ayurvedic sage, elevated Yukti to the status of the fourth Pramana, a significant contribution to the field. Yukti provides a framework for understanding the trikaala (past, present, future) and trivarga (dosha, dhatu, mala) aspects of health and disease. It is indispensable in various research domains, including drug discovery, standardization, pharmaceutical development, observational studies, pathological investigations, experimental research, and animal studies. The integration of Yukti ensures the efficacy and safety of Ayurvedic interventions. This review critically examines classical Ayurvedic texts, contemporary literature, and electronic databases to explore the multifaceted applications of Yukti. Systematic reviews and meta-analyses were employed to synthesize evidence. The findings underscore the importance of Yukti as a cornerstone of Ayurvedic research. It serves as a roadmap for effective planning (Karya Yojana), a critical component of Charaka's Chaturvedi Pareeksha. Yukti empowers researchers to develop evidence-based treatment protocols, design rigorous research studies, and establish robust drug standardization procedures. By understanding and applying Yukti, postgraduate students can conduct well-planned research that contributes to the advancement of Ayurveda and improves patient outcomes.

KEYWORDS: Ayurveda, Clinical Trials, Drug Research, Guna, Pariksha, Pramana, Research, Standardization, Trikaala, Trivarga, Yukti.