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Introduction: Human beings developed health care system from the beginning of human thoughts, but diseases were still flourishing and people felt health problems. According to Ayurveda, various types of ailments appear with development of human living systems. Ayurveda is a medical system that covers all the facts of life and is defined as the science of Dravya, Guna, Karma keeping the view of Hita-Ahita, Sukha-Asukha through Pramana-Apramana. Some previous works have been done related to Paradi Gunas, but no compiled study has been done yet. Materials: Ayurveda classical texts and Rasashastra texts. Methodology: Conceptual study of Paradi Gunas in Ayurveda. Application of Paradi Gunas in Drug preparation in reference to Rasashastra texts. Discussion: Rasashastra texts play a vital role in Ayurvedic pharmacology. These texts are ancient Indian documents that focus on the preparation and utilization of metallic and mineral substances for medicinal purposes. They provide comprehensive knowledge and guidelines on the processing, purification, and combination of various minerals and metals to create potent medicines. Rasashastra texts also contribute to the understanding of the properties and actions of these substances. They describe the specific qualities, tastes, and therapeutic effects of each mineral and metal, helping practitioners select the most appropriate ingredients for a given condition. Results: By following the instructions outlined in Rasashastra texts, Ayurvedic practitioners can create personalized herbal formulations tailored to individual patients' needs.

KEYWORDS: Ayurvedic pharmacology, Drug development, Drug manufacturing, Paradi gunas, Rasashastra texts,